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Biocompatibility




   

Trabecular TitaniumTM is made from Titanium, one of the most biocompatible materials used in orthopaedic implants1.
In vitro genetic expression analysis on human osteoblast-like cells demonstrated that Trabecular TitaniumTM is able to enhance osteoblast proliferation and differentiation and limit osteoclastogenesis. Furthermore, it has been proven that it induces a down-regulation of several genes involved in the inflammatory process and modulates genes related to immune system2.

[1] Buddy D Ratner. A Perspective on Titanium Biocompatibility. In: Brunette DM, Tengvall P, Textor M, Thomsen P, editors. Titanium in Medicine: Material Science, Surface Science, Engineering, Biological Responses and Medical Applications. New York: Springer Verlag; 2001. pp 1-12.

[2] Sollazzo V, Massari L, Pezzetti F, Palmieri A, Girardi A, Farinella F, Lorusso Vincenzo, Burelli S, Bloch HR, Carinci F. Genetic effects of Trabecular Titanium™ on human osteoblast-like cells (MG-63): an in vitro study. ISRN Materials Science. 2011:392763.